From 1852 to 1863 he had a highly successful career as a concert violinist throughout Europe and Russia; performing in the courts of several monarchs and with the great orchestras of the day.
[1] In June 1865 Jehin-Prume came to Canada for the first time to visit his friend, violinist Jules Hone, for a fishing and hunting vacation.
What initially was supposed to be a short visit to Canada, turned into a permanent home; a fact solidified by his marriage to Montreal mezzo-soprano Rosita del Vecchio in July 1866.
He was the first concertmaster of the Montreal Philharmonic Society and served as the president of the Académie de musique du Québec in 1877–1878.
In 1892 he founded the first professional chamber music society in Quebec, the Association artistique de Montréal, which mounted a total of 31 concerts before it disbanded in May 1896.
He was also active as a teacher and counts several notable musicians among his pupils, including François Boucher, Alfred De Sève, Béatrice La Palme, and Émile Taranto.