Franz Penzoldt (12 December 1849 – 19 September 1927) was a German internist and pharmacologist born in Crispendorf, Principality of Reuss-Greiz.
He studied medicine in Tübingen and Jena, where he was a student of Wilhelm Olivier Leube (1842–1922).
In 1875, he obtained his habilitation at Erlangen, where he later became a professor of internal medicine and pharmacology.
He was the author of the popular Lehrbuch der klinischen Arzneibehandlung für Studierende und Ärzte (Textbook of Clinical Pharmaceutical Treatment for Students and Physicians), which was published over numerous editions.
Today the "Franz-Penzoldt-Zentrum" at the University of Erlangen-Nuremberg is named in his honor.