The plant is endemic to California, where it is known from the Western Transverse Ranges in the Greater Los Angeles region, and the Southern California Coast Ranges.

Frasera neglecta is a perennial herb producing one or more erect stems from a rosetted base, reaching up to roughly half a meter tall.

The leaves are linear or lance-shaped and green with white margins; the largest leaves at the base of the plant can reach 20 centimeters in length.

The inflorescence is a dense panicle atop the stem, sometimes interrupted into a series of clusters of flowers.

There are four stamens tipped with large anthers and a central ovary.