Frederick Romaine Applegate (May 9, 1879 – April 21, 1968) was a Major League Baseball pitcher in 1904 for the Philadelphia Athletics.

Between September 30 and October 10, he started and completed three games, winning 1 and losing 2 with an ERA of 6.43.

His lone major league win came against the Washington Senators in his third and final start.

A good hitter and fielder during his brief time in the big leagues, he batted .286 (2-for-7) and handled eight chances without making an error.

A native of Williamsport, Pennsylvania, he died in his hometown at the age of 88.