Frederick I of Mecklenburg-Grabow, Duke of Mecklenburg-Grabow (13 February 1638, Schwerin – 28 April 1688, Grabow) He was the son of Adolf Frederick I, Duke of Mecklenburg-Schwerin and his second wife Marie Katharina (1616-1665), daughter of Julius Ernst, Duke of Brunswick-Dannenberg (1571-1636).
Through his late birth, he was excluded from active government and was an "apanagierter"[clarification needed] prince.
Via the death of his brother without issue Frederick I's three sons became ruling duke of Mecklenburg [-Schwerin] one after the other.
In 1667 Frederick became Domherr of Strasbourg Cathedral and from 1669, he lived in the family castle in Grabow.
Frederick died in a fire in the castle and was on 3 June 1725 buried in the Schelfkirche St. Nikolai in Schwerin.