Landgravine Christine Wilhelmine of Hesse-Homburg (30 June 1653, in Bingenheim – 16 May 1722, in Grabow) was a German noblewoman, the elder daughter of William Christoph, Landgrave of Hesse-Homburg and his first wife Sophia Eleonore of Hesse-Darmstadt.

Upon her marriage she became the Duchess of Mecklenburg-Grabow.

Her great-grandson was Ivan VI of Russia.

[1][2] On 28 May 1671 she married Frederick, Duke of Mecklenburg-Grabow, son of Adolf Frederick I, Duke of Mecklenburg and Marie Katharina of Brunswick-Dannenberg.

They had the following children:[1][2]