Frederick was the son of Charles III William, Margrave of Baden-Durlach, and Magdalena Wilhelmine of Württemberg (7 November 1677 - 30 October 1742), the daughter of William Louis, Duke of Württemberg.

He became heir apparent when his elder brother Charles Magnus died in 1712.

In 1724, he was appointed colonel, in 1728, he was promoted to major general.

On 3 July 1727, Frederick married Amalia of Nassau-Dietz (born 13 October 1710, died 17 September 1777), the daughter of John William Friso, Prince of Orange.

[1][additional citation(s) needed] They had the following children: This article about a member of the German nobility is a stub.