Frederick was born in 1417 to Stephen, Count Palatine of Simmern-Zweibrücken and his wife, Anna of Veldenz.

In 1444 his father partitioned his territories between Frederick and his younger brother Louis.

Frederick married Margaret of Guelders, daughter of Duke Arnold, on 16 August 1454.

Frederick died in Simmern in 1480 and was buried in the Augustinian Abbey of Ravengiersburg.

With Margaret (1436 – 15 August 1486), daughter of Arnold, Duke of Guelders: