It runs from Kultorvet square in the southeast to Søtorvet where Queen Louise's Bridge connects it to Nørrebrogade in Nørrebro on the other side of The Lakes.

The short, southern portion, together with Kultorvet and Købmagergade, forms a pedestrian zone between the station and Strøget at Amagertorv.

[1] The current street name was introduced in the form Frederiksborger Gade in connection with the move of the city's North Gate was moved to the northern end of the street from its old position a little further to the west at the end of Nørregade.

[3] The intersection with Nørre Farimagsgade became the busiest junction in Copenhagen and Denmark's first automatic traffic lights were installed at the site on 23 November 1928.

Am Art Deco-style stone pillar designed by Peder Vilhelm Jensen-Klint marks the point where Copenhagen's North Gate was once located.