[6] Concerns about the possibility of heavy bombing casualties led to the hospital being greatly expanded between 1938 and early 1942.

[7] When US forces arrived in 1942, the city handed the new hospital facilities over to the Americans, as a sort of reverse Lend-Lease.

A Save Frenchay Hospital campaign was fronted by Steve Webb, the local Member of Parliament.

The campaign's main arguments were that Frenchay Hospital afforded greater possibility for expansion than the Southmead site and that emergency access was easier due to its proximity to the motorway.

[12] An extension was built at the Bristol Royal Hospital for Children to accommodate child services which moved from Frenchay in March 2014, including neuroscience, scoliosis surgery, burns and plastic surgery, bringing all inpatient child services in Bristol to one location.

[13][14] The accident and emergency department was transferred to the new Southmead Hospital on 19 May 2014, following local advertising of the change.