The Friendship Highway (also known as the China-Nepal Highway, Chinese: 中尼公路; pinyin: Zhongni Gonglu) is an 800-kilometre (500 mi) scenic route connecting the capital of Tibet, Lhasa, with the Chinese/Nepalese border at the Sino-Nepal Friendship Bridge between Zhangmu and Kodari.

The main route continues along the Yarlung valley up to Shigatse, Tibet's second-largest city and formerly the home of the Panchen Lamas.

From Shigatse, continuing west parallel to the Yarlung Tsangpo valley, the road passes Lhatse and forks just beyond at Chapu, where China National Highway 219 continues west and upriver, finally crossing the Brahmaputra/Indus divide near sacred Mount Kailash and Lake Manasarovar, then on to Ali in Gar County.

From Chapu near Lhatse, the Friendship Highway maintains the Hwy 318 route number and turns southwest and crosses the main Brahmaputra-Ganges divide at Gyatso La (5,260 m (17,260 ft)), the highest pass on the road.

Scenery along the highway features important cultural monuments, the upper valley of the Yarlung Tsangpo (Brahmaputra) River, vast grasslands and meadows, and mountain vistas including five of the world's highest peaks: Everest, Lhotse, Makalu, Cho Oyu and Shishapangma as well as partially unexplored and unclimbed peaks east of Tong La reaching 7,367 m (24,170 ft) at Labuche Kang.