Originally anchored by Raffy Tulfo and Cheryl Cosim, it premiered on October 5, 2020, replacing Aksyon.

Delivering News from the Frontlines) and "Tapat at tamang pagbabalita para sa may alam at may pakialam" (transl.

Frontline Pilipinas premiered on October 5, 2020, at 6:30 PM PHT with Raffy Tulfo and Cheryl Cosim as original anchors, along with News5 chief Luchi Cruz-Valdes, chief correspondent Ed Lingao, and Lourd de Veyra as segment anchors for Deretsahan, NEWS ExplainED, and Word of the Lourd, respectively.

[7][8] On February 15, 2021, athlete and TV host Gretchen Ho joined the newscast as "Sports" segment anchor (alongside The Big Story on One News).

[10] On April 5, 2021, the program moved to 5:30 PM with a shortened one-hour running time to give way for the new shows Sing Galing!

[11] On July 16, 2021, the show cut its airtime to 30 minutes on Wednesdays and Fridays to give way to the broadcast of the 2021 PBA season.

[14] In conjunction with this, Frontline Pilipinas also debuted its new opening billboard, title card, and graphics.

Babao was originally to make his debut on January 17, but was postponed due to the increasing number of COVID-19 cases brought by the omicron variant.

[16] Also on the same day, Gretchen Ho took over the anchoring duties for Frontline sa Umaga from Paolo Bediones as he left News5 on February 1 due to the issues surrounding his company, Ei2Tech.

[17] In conjunction with this, Frontline Pilipinas also debuted its new opening billboard, title card, and graphics for the second time.

[18] From June 24, 2024 to February 10, 2025, the program's final 30 minutes were pre-empted on TV5 and One PH to accommodate Lumuhod Ka Sa Lupa and Gus Abelgas Forensics, respectively.

On January 17, Bediones left the newscast due to pending lawsuits filed by former employees of Ei2 Technologies, Inc.[26] Halili served as the interim anchor.

Meanwhile, it was replaced by the replay of Julius at Tintin: Para sa Pamilyang Pilipino on its timeslot on 92.3 Radyo5 True FM.

It is also aired on RPTV as a slightly delayed basis on February 1, 2024, replacing The Final Word with Rico Hizon on CNN Philippines late night timeslot.

[38] Frontline Pilipinas received nominations for Best News Program and Best Female Newscaster (Cosim) at the 35th PMPC Star Awards for Television.