[1][2][3][4][5] It is an aggrupation of the news division units within the MediaQuest group, namely TV5 Network's News5 division, and the Philstar Media Group's newspapers The Philippine Star and BusinessWorld.

In 2019, TV5 began airing selected programs from One News, such as Agenda with Cito Beltran and The Chiefs.

On March 17, 2020, One News along with One PH, temporarily suspended its regular programming as an effect of the island-wide "enhanced community quarantine" against COVID-19 in Luzon.

Several programs from Bloomberg Television, One PH, and PBA Rush as well as third-party content partners (including Probe Productions) are also aired on the channel.

One News Now served as a replacement for both Rush (formerly Rush Hour) and One Newsroom on One News starting March 17, 2020 due to the enhanced community quarantine caused by the COVID-19 pandemic.