[3] Frosolone is known historically for the production of blades,[4] including knives and scissors, and is home to a museum dedicated to the craft.

The region surrounding Frosolone was inhabited by members of the Sanniti and Osci Italic tribes, which were conquered by the Romans during the Samnite Wars.

As the name implies, they were likely part of a small fortress destroyed by the Roman Army probably in 293 BC; the historian Livy describes in this area the march of two Roman armies, headed by Spurius Carvilius Maximus and Lucius Papirius Cursor.

Frosolone was victim to another earthquake on July 26, 1805, which destroyed most of the buildings in town and killed 518 people.

In 1864 the Post Office was opened; in 1866 a kerosene public lighting system was installed at the then-large outlay of 4,000 lira.