The camera was announced on January 27, 2021, at the X Summit Global 2021 together with the GFX100S.

It is part of the company's X-series range of cameras positioned for enthusiast photographers.

[4] The camera consists of the same 26.1-megapixel, back-side illuminated but with a newer processor, the X-Trans CMOS 4 sensor which is also found in FujiFilm's flagship cameras.

In September 2022, major Japanese retailers started listing the Fujifilm X-E4 as discontinued.

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