U.S. Route 78 crosses the waterway at an overpass south of the Fulton Lock.

The Fulton Lock is located at mile 391 on the waterway, representing the navigational distance from the southern end of the waterway at the Cochrane–Africatown USA Bridge on U.S. Route 90 in Mobile, Alabama.

[1] The Fulton Lock was constructed at a cost of $28.3 million, and it created a 1,643 acres (665 ha) lake north of the dam.

Located on the lake are two recreation areas, as well as the Whitten Historical Center.

For large vessels, lock operations are made on demand.