In 1842 she made her debut at the Esposizione di Belle Arti at the Brera Academy and assiduously participated in the following editions of the exhibition until 1859.
After being awarded a prize at the Brera Academy in 1845 for a large mountain landscape, Bisi became established on the Milanese art scene as an heir to the Romantic Lombard tradition.
She began to exhibit frequently and participated in the main shows in Turin, Parma and Florence, at the 1881 Esposizione Nazionale in Milan and in Venice in 1887, and was a notable success on the market.
In her maturity she achieved a signature style characterised by a vibrant handling, consisting of short brushstrokes and a particular sensibility to the atmospheric and luministic values of landscape.
At the 1880 Exhibition of Turin, she submitted a Monte Rosa veduto da Alagna e Valgonna (views of Lombardy).