Fumone is a comune (municipality) in the Province of Frosinone in the Italian region of Lazio, located about 70 kilometres (43 mi) southeast of Rome and about 12 kilometres (7 mi) northwest of Frosinone.

The town is on an isolated conical hill upon the Sacco Valley.

It borders with the municipalities of Alatri, Anagni, Ferentino, and Trivigliano.

The castle of Fumone was the main Papal stronghold in southern Latium.

Also notable is the church of Santa Maria Annunziata, which houses relics of St. Sebastian.