Thrush is a common infection that occurs on the hoof of a horse, specifically in the region of the frog.

F. necrophorum occurs naturally in the animal's environment, especially in wet, muddy, or unsanitary conditions, such as an unclean stall.

[13][14] Horses with deep clefts, or narrow or contracted heels are more at-risk to develop thrush.

This can occur due to strong footbaths, sandy soils, mild frostbite, or prolongened waterlogging of a field, and results in denaturing of the skin between the cleats.

[15] F. necrophorum is the cause of necrotic laryngitis ("calf diphtheria")[16] and liver abscesses[17] in cattle.

"Subcutaneous Immunization with Inactivated Bacterial Components and Purified Protein of Escherichia coli, Fusobacterium necrophorum and Trueperella pyogenes Prevents Puerperal Metritis in Holstein Dairy Cows".