Several Congressional High Priority Corridors have been designated as future parts of the Interstate Highway System by the Intermodal Surface Transportation Efficiency Act and amendments.

An alternate proposed terminus is located at the I-5/US 50/Capital City Freeway junction in Sacramento, where the future Interstate(s), after continuing north from Stockton along Route 99, can turn west along the Capital City Freeway, already an Interstate route (unsigned I-305), to connect with I-5, which extends north toward Redding.

[6] The route is to remain roughly parallel to I-5, serving major cities in California I-5 does not, including Fresno and Bakersfield.

[7] On May 20, 2021, Senator Jim Inhofe, of Oklahoma, introduced legislation to designate the portion of US 412 between I-35 in Noble County and I-49 in Springdale, Arkansas as future Interstate 42 (I-42).

The senators' stated reasons for seeking an Interstate designation along US 412 included encouraging economic development, expanding opportunities for employment in the region, making travel safer and shipping easier, attracting new businesses, and better connecting rural and urban communities.

Other supporters of the measure include Mayor G. T. Bynum of Tulsa, and the heads of both ODOT and the Arkansas Department of Transportation (ArDOT).

[14] The Michigan State Highway Department officially requested switching the I-67 designation to a route from Benton Harbor to Grand Rapids in 1958, and in the process proposed the northerly extension of the original I-69 from the I-80/I-90/Indiana Toll Road to Lansing.

The Indiana Senate unanimously passed a resolution calling for federal funding for this proposal and the I-67 designation in 2003.

[17] Meanwhile, Indiana expedited the upgrading of three major sections on US 31 between Indianapolis and South Bend including the Kokomo Bypass.

It would use the Natcher Bridge to cross the Ohio River, Kentucky's I-165 and Indiana's Lincoln Parkway, an expressway facility that would need to be fully upgraded to Interstate standards.

It would go around the cities of Jasper and Huntingburg in Indiana as well as Owensboro, Hartford, and Morgantown, Kentucky, and end at Bowling Green.

In 2006, the Virginia General Assembly directed the Secretary of Transportation to initiate a study to determine the interest of affected states in the construction of a new Interstate highway (I-99).

This would be separate from the existing Interstate 99 in New York and Pennsylvania, and unlike the current route, would fall into its place on the numbering grid.

I-274 first appeared on North Carolina Department of Transportation (NCDOT) planning maps in the early 2000s but was later disused for over a decade since.

On May 20, 2019, the American Association of State Highway and Transportation Officials (AASHTO) approved a request to establish Future I-274.

Justification given by NCDOT was that the 16.83-mile (27.09 km) section would satisfy a great need to alleviate congestion in Winston-Salem and connect the western portion of the urbanized area.

From there, it will continue northward to an extension of Illinois Route 390 (IL 390, formerly known as the Elgin-O'Hare Expressway) and I-90 (Jane Addams Memorial Tollway).