Official premise by DC Comics: When the adventurous and inquisitive Jonny Quest and his adoptive brother Hadji make a startling discovery in the swamplands of Florida, they are pulled into an epic struggle between the Space Rangers and a dangerous villain who threatens the galaxy.

Now it’s up to the combined forces of Team Quest, Inter-Nation Security, Space Ghost, and a host of Hanna-Barbera’s greatest action heroes to stop him and save their universe!

In the swamplands of Palm Key, Florida, Doctor Quest is tracking mysterious phenomena such as unnatural storms, and glimpses into other areas of the galaxy known as vortexes.

Space Ghost's Phantom Cruiser unexpectedly crash lands, and Jonny Quest, Hadji, and Race Bannon are sent to investigate.

With the help of Race Bannon, they rescue Jonny, Hadji, Ty, an amnesiac girl from the ship, and a strange monkey.

Back at the Quest compound, Deva tells Ty it is safer he remain under Inter-Nation's protection, as he will now be a target of F.E.A.R.

They arrive, and are met by Todd Messick, young adventurer whose parents mysteriously disappeared in the area they landed in, known as the "Lost Valley".

Deva, convinced the Impossibles are not prepared to face such a threat, takes off to California with Race Bannon and Doctor Conroy, instructing the kids to stay in the lab.

Meanwhile, at the lab, Jan recovers her memory, and tells Jonny, Hadji, and Buzz that Omnikron is a massive intergalactic parasite that feeds off of life, and destroys entire ecosystems.

leader, Number One, with mind control, and the boy he recovered from the crash site, was Jan's brother Jace.

The odds turn even more in the heroes' favor when Birdman and Mightor escape from the vortex, joining the fight.

The original Mightor says he has happy the club did not fall into the hands of the "Sky-god" (Omnikron), and teaches him to open a vortex to any location he is familiar with.

Multi-Man of the Impossibles creates the illusion of a massively clustered population in the Grand Canyon to bait Omnikron into returning to Earth.

The heroes take advantage of this, and Mightor opens a vortex just outside Earth's atmosphere, and Space Ghost, Jan, and Jace fly through, and blast Omnikron into the Sun with the Phantom Cruiser.

The heroes celebrate, and Birdman says the boys were able to take control by not holding onto psychological demons adults hang onto.