The Guangzhou–Kunming Expressway (Chinese: 广州—昆明高速公路), designated as G80 and commonly referred to as the Guangkun Expressway (Chinese: 广昆高速公路) is an expressway in China that connects the cities of Guangzhou, Guangdong, and Kunming, Yunnan.

When complete, it will be 1,511 km (939 mi) in length.

The section of roadway from Suolongshi, Mile County, Honghe Hani and Yi Autonomous Prefecture, Yunnan to Shilin Yi Autonomous County still follows China National Highway 326 which is not a grade-separated expressway.

It is currently being upgraded to expressway standards.

Note: italic indicates the routes that were available in 2013 network plan, but removed in 2022 network plan