On November 6, 2018, Acevero finished in first place with 31% of the vote and became the first openly gay Afro-Latino, and one of the youngest people, elected to the Maryland House of Delegates.

[6] A Black Lives Matter activist, Acevero helped organize and participated in protests during the 2015 Freddie Gray unrest in Baltimore City.

Acevero joined the coalition of activists and organizations that pushed for the repeal of Maryland's Law Enforcement Officers Bill of Rights (LEOBR) following Freddie Gray's death.

[7] Acevero joined the Maryland Fight for $15 campaign and organized low-wage workers and community groups to support raising the minimum wage in Montgomery County.

[8] In December 2017, Acevero was one of a group of activists, labor leaders, clergy, and lawmakers arrested on the steps of Capitol Hill for engaging in an unlawful demonstration.

He was also behind the push that led to renaming a Rockville, Maryland, elementary school in honor of gay civil rights leader Bayard Rustin.

In his testimony before the Montgomery County Board of Education, Acevero criticized the Trump administration's decision to remove LGBTQ people off the US Census and the transgender military ban: "We have a hostile administration that is intent on erasing LGBTQ folks, recently taking us off the Census and banning transgender Americans from serving their country.

[9] Acevero ran in the three-member house district, which includes parts of Gaithersburg, Germantown, Clarksburg, Montgomery Village, and Washington Grove.

[14][better source needed] During the 2024 Democratic Party presidential primaries, he urged voters to cast an "Uncommitted" protest vote against President Joe Biden for his handling of the Israel–Hamas war.

[24] Gino Renne, president of Montgomery County Government Employees Organization Local 1994 (MCGEO), had expressed concern over Acevero's support of the legislation.

[33] Due to the timing of this legislation and because it did not adhere to the Court's recommendation of using a nonpartisan redistricting commission to draw the new borders, Acevero could not support the bill in its introduced form.

In 2021, Acevero was the only Democrat in the entire Maryland General Assembly to vote against House Bill 1, the legislature's congressional redistricting plan, citing concerns of the heavy use of gerrymandering and splitting up of communities.

He called on legislators from both parties to support the For the People Act, due to its creation of state-level commissions for drawing Congressional Lines.

[38] In May 2023, Acevero and delegate Ashanti Martinez signed onto a letter condemning the censure of two transgender legislators—Zooey Zephyr and Mauree Turner—in Montana and Oklahoma.

[42] Acevero called the idea as a "form of social security, and it is one of the most transformative policies that we can enact at the state and federal level to put a dent in extreme poverty," and pointed to Alaska's use of it to combat income inequality.