Michele Jenkins Guyton (born October 19, 1966) is an American politician from the Democratic Party and is a member of the Maryland House of Delegates representing District 42B.

[7] Mileah Kromer, a political scientist and pollster at Goucher College, suggested that Guyton's primary win indicated a polarized electorate in Maryland's 42nd district.

[14] In February 2020, Guyton joined seven Democratic delegates in voting against a bill that would mandate background checks on private sales and transfers of shotguns and rifles.

[14] On the campaign trail, Guyton advocated for the legislature to pass a "$15 an hour living wage with future indexed increases.

[17] Guyton opposes raising new taxes, instead advocating for redirecting priorities and using funding sources like lottery money and the legalization of marijuana.