As an actor, he has appeared in numerous live-action and animated TV shows and films, including starring in the sitcom Mr. Iglesias on Netflix, playing Tobias in the 2012 movie Magic Mike and its 2015 sequel, and providing the voice of Speedy Gonzales in Space Jam: A New Legacy.

He lived in Riverside, Corona, Santa Ana, Baldwin Park, and Compton before settling in Section 8 low-income housing in Long Beach, where Iglesias spent most of his youth.

[16] Regarding how novice comedians can widen their fan base, Iglesias stated in a January 2016 interview:[17] In the beginning, work as clean as you possibly can and stay away from topics that could be controversial or offensive.

[20] In an 2024 interview with Neal Brennan, Iglesias stated that he did not grow up with a specific religion despite his family being originally Roman Catholic, since his mother held syncretist beliefs regarding religion—for example displaying crucifixes and images of the Virgin Mary alongside Buddha and Ganesh statues and wearing a Star of David necklace.

He remained uncatechized and mostly uninvolved in organized religion during his upbringing, occasionally going to church on a friend's invite but ultimately shaping his moral framework based on his mother's guidance and personal experiences.

[22] In The Fluffy Movie, Iglesias describes how at his heaviest, which he states was 445 pounds (202 kilograms), he was diagnosed with type 2 diabetes, and with his blood sugar spiking to over 300 mg/dl (16.6 mmol/L) regularly, was given two years to live by his doctor.

He said the shock of being told this had prompted him to reevaluate how he took care of himself and explained that he decided to lose weight in order to ensure his continued presence in the lives of his family.

Iglesias described the struggle to incorporate a healthier lifestyle, relating how he was told by a specialist that his heavy touring schedule precluded him from being a candidate for bariatric surgery, and how he instead resorted to weight-lifting, Diamond Dallas Page Yoga, and a high-protein, low-carbohydrate diet, which helped him shed over 100 pounds (45 kilograms).

[21] On July 15, 2021, his 45th birthday, Iglesias tested positive for COVID-19, and cancelled his remaining shows at the Tobin Center for the Performing Arts as well as the taping of his upcoming comedy special.