Gaetano T. Montelione is an American biophysical chemist, Professor of Chemistry and Chemical Biology, and Constellation Endowed Chair in Structural Bioinformatics at Rensselaer Polytechnic Institute in Troy, NY.

He was promoted to the rank of Distinguished Professor and appointed as the inaugural holder of the endowed Jerome and Lorraine Aresty Chair in Cancer Research.

[6] The NESG program developed new technology for protein sample production, NMR, X-ray crystallography, and structural bioinformatics.

[9]  At Rutgers, he followed up this work by development of the HCCNH-TOCSY, HCCcoNH-TOCSY, and related triple-resonance NMR experiments used for determining resonance assignments and 3D structures of proteins.

Montelione has made key contributions in computational NMR methods development, including the development of software for automated analysis of protein resonance assignments, automated analysis of 3D structures, and for protein NMR model quality assessment.