Gain (ISBN 0-374-15996-3) is a novel by Richard Powers published by in 1998.

It tells the stories of Clare International, a chemical conglomerate with origins in soap manufacturing in the early 19th century, and Laura Bodey, a 42-year-old divorcée living near Clare International's headquarters who develops ovarian cancer.

It won the James Fenimore Cooper Prize for Best Historical Fiction in 1999.

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