Gainesville is an unincorporated community in Greene County, Arkansas, United States.

[1] Once a thriving settlement and county seat, little remains today of the former community.

[2] The settlement was located on an improved road leading to Helena, Arkansas.

[2] On June 28, 1861, the 5th Arkansas Infantry Regiment of the Confederate Army was organized at Gainesville.

[5] Prior to the 1880s, Gainesville was the largest settlement in Greene County, with a population of about 230.