In 1352 Malatesta led a campaign in Abruzzo in the service of Louis of Anjou, King of Sicily, and laid siege to the fortress of Aversa, held by the mercenary leader Fra' Moriale.
[1] In 1353 Innocent VI sent Gil Álvarez Carrillo de Albornoz as a legate into Italy, with a view to the restoration of the papal authority in the states of the Church, at the head of a small mercenary army.
The Papal commander Rodolfo II da Varano, lord of Camerino, defeated Galeotto Malatesta, forcing his family to become an ally of the Pope.
In 1372 Pope Gregory XI confirmed Galeotto general commander of the Papal Army against Bernabò Visconti, whom he defeated at Montichiari, near Brescia, the following year.
After the death of his nephews, Galeotto managed to gain the whole family seigniory in Romagna (he had been already lord of Rimini from 1364 with Ungaro IV and Pandolfo II Malatesta, as well as sole ruler of Fano).