[1][2] Gambogic acid is the principal pigment of gambooge resin which, in addition to early traditional medicinal uses in Southeast Asia, is also a sought after dye due to the bright orange color it imparts to cloth.

[3] According to traditional Chinese medical documentation, gamboge was described as poisonous and acidic and possessed the ability to detoxify, kill parasites, and stop bleeding as a hemostatic agent.

Results supported the hypothesis that gambogic acid works to suppress nuclear factor-κΒ (NF-κΒ) activation that is induced by various inflammatory agents and carcinogens.

[4] Results indicate that cell growth is dependent on both the magnitude of the dose administered as well as the length of time exposed to gambogic acid.

[8] In mice gambogic acid causes developmental toxicity in a dose-dependent manner, including low birth weight and inhibitory effects on fetal skeletal development.

[8] Analyzing mice that received the 4 mg/kg and 8 mg/kg doses, there was no substantial weight loss, no gastrointestinal reactions to medication, no obvious changes in any vital organs, and no fatalities.