Created in 2012 by co-hosts Hanson and Jon Jafari, the series centers around its hosts playing video games.

Those include Ross O'Donovan, Barry Kramer, Suzy Berhow, and Brian Wecht, as well as various guest hosts.

[1] GameGrumps have also developed and published three of their own video games, Dream Daddy: A Dad Dating Simulator, Soviet Jump Game, and Homebody, as well as writing the young adult novels Ghost Hunters Adventure Club and the Secret of the Grande Chateau and Ghost Hunters Adventure Club and the Express Train to Nowhere.

[4][5] After Jafari's departure, Ninja Sex Party vocalist Dan Avidan succeeded him as co-host of the main show.

[4][5] Avidan also joined animator Ross O'Donovan as co-host of the show Steam Train where both play PC games.

[11] In January 2015, to celebrate reaching two million subscribers, a new show called Grumpcade was launched, featuring any combination of co-hosts playing console games.

In November 2015, Avidan's Ninja Sex Party bandmate Brian Wecht officially joined the team, leaving behind his career as a theoretical physicist.

[12] In February 2016, it was announced that Avidan and Hanson would appear at Hollywood Improv for a special performance of GameGrumps Live on March 30 and 31.

[16] In December 2017, Kramer announced that he would be departing from the show to focus on his own pursuits; he was replaced by Ryan Magee and Matt Watson.

Aside from Jon Jafari and Barry Kramer, GameGrumps has had a few editors who, aside from various appearances, were not necessarily dubbed as official members.

In late 2013, the GameGrumps had put various games, which they had received multiple copies of, on eBay for auction, with all the proceeds going to the children's charity Child's Play.

In the end, O'Donovan was the sole winner, and, combined with the participants' distributed funds, donated $5,000 to cancer research.

[25] On February 17, 2018, GameGrumps held a 6-hour livestream on Twitch in which they played several games, including Mad Max, Half-Life 2, Fallout, and Overwatch, raising around $77,000 for the Crisis Text Line.

These include live-action comedy shows 10 Minute Power Hour and Good Content, Good Game, a YouTube Premium exclusive show,[29] and two GameGrumps-published books, Ghost Hunters Adventure Club and the Secret of the Grande Chateau and Ghost Hunters Adventure Club and the Express Train to Nowhere, supposedly written by Hanson's estranged uncle Dr. Cecil H.H.

[30][31] The audiobook version of Ghost Hunters Adventure Club and the Secret of the Grande Chateau was released on Audible on August 19, 2020, narrated by Hanson in character as Dr. Cecil H. H. Mills.

The second book in the series, Ghost Hunters Adventure Club and the Express Train to Nowhere, was published on June 7, 2022, accompanied by its own theme song.

The video also featured other internet personalities Jesse Cox, Brooke "Dodger" Lawson, Mike Lamond and John Bain.

[39] In an interview with Entertainment Weekly, Olympic swimmer Tom Shields said that GameGrumps was one of his favorite shows and that he watched it "almost daily."