The game follows the episodic format found in other Telltale titles, where player choices and actions influence later events across the six-episode arc.

The story revolves around the northern House Forrester, rulers of Ironrath, whose members, including the five playable characters, attempt to save their family and themselves after ending up on the losing side of the War of the Five Kings.

The game includes settings and characters from the series of novels A Song of Ice and Fire and the television adaptation.

Emilia Clarke, Iwan Rheon, Kit Harington, Lena Headey, Natalie Dormer, and Peter Dinklage reprise their roles from the television series as Daenerys Targaryen, Ramsay Bolton, Jon Snow, Cersei Lannister, Margaery Tyrell, and Tyrion Lannister, respectively.

George R. R. Martin stated that his personal assistant, Ty Corey Franck, was working with Telltale Games as a "story consultant".

The story focuses on House Forrester, a family not introduced in the television series, but mentioned briefly in the novel A Dance with Dragons.

House Forrester hails from Ironrath, a fortress within the Wolfswood forest in the North of Westeros, where they control the valuable Ironwood groves, coveted by many because of the wood's military importance.

[14] Throughout the game, the player controls one of 5 family members or servants of the Forresters, with decisions made by one character affecting the others, and the ultimate fate of the house.

[7] Game of Thrones received mixed reviews from critics praising the narrative, choice driven gameplay, and faithfulness to the source material while criticism was directed towards the graphical glitches and the lack of context for players unfamiliar with the Game of Thrones franchise.

[33] Gamezebo's reviewer noted that Episode 2, in particular, exhibited poor performance on iOS devices, with glitches and stuttering affecting the player's ability to succeed at timed events.