In the Treta Yug, Sushena (the expert physician from Lanka who was chief of medicines, Shri Hanumana requested him and carried him with his entire palace to the place where Shri Laxmana was lying injured) had suggested Vir Hanuman to bring Bisalyakarani ere dawn, so that Laxman would rise back to life.

Sage Drona residing on this mountain belonging to the Mahabharat period used to deliver art of weaponry to the selected few pupils and he was famous for it across the country.

Many scholars believe that this mountain (and not Nagarjunakonda) was the site of the monastery of Nagarjuna, which Hiuen-Tsiang referred to as Po-lo-mo-lo-ki-li (restored to "Paramalagiri" by Julien).

Local people have great faith in Ayurvedic practitioners and in many villages, their main occupation is to collect herbs and supply them to companies such as Dabur and Zandu.

A study conducted by M Brahma and H O Saxena of the Regional Research Laboratory recorded the medicinal uses of nearly 200 species, out of which they found the uses of 77 to be new or "interesting'.

The local communities and the peoples movement in Gandhamardhan hills have been largely responsible for preserving the rich biodiversity of the region.