Reed wrote over 200 comics and graphic novels, sometimes under assumed names (including Kyle Garrett, Brent Truax, and Randall Thayer).

[4] In 2010, Reed would join Detroit Fanfare Conventions as an adviser and serve on its board of directors.

In 1989, Reed launched Caliber Comics, an independent publishing company which gave exposure at an early stage of their careers to many of today’s top comics talents, including Brian Michael Bendis, David W. Mack, Vince Locke, Guy Davis, Michael Lark, Patrick Zircher, Jim Calafiore, Ed Brubaker, Michael Gaydos, James O'Barr, Kevin VanHook and Mike Carey.

The initial titles were Deadworld, Realm, Caliber Presents, Moontrap, The Crow, and Baker Street (a series co-created by Reed with Guy Davis).

Reed concentrated on his teaching until 2004, when he started working with Byron Preiss, who contracted to reprint all of the issues of Baker Street in a single collection to be distributed by Simon & Schuster.

In 2009, he released A Murder of Scarecrows through Desperado as well as a hardcover original tale of Deadworld in Slaughterhouse with art by Hatter M's Sami Makkonen.

Featuring titles centered on The Rocky Horror Picture Show and cartoonists such as Jack Davis.

[14] In 2014, Reed announced that he was bringing Caliber Comics back, in a partnership formed with Eagle One Media’s Eric Reichart.

In addition to his freelance writing, Reed taught various biology-related courses at several community colleges in his area.

In 2012, Reed was presented with a special Shel Dorf Award for his contributions to the comic industry.