[18] Siuzdak has also made contributions to virus analysis,[19][20] viral structural dynamics,[21][22][23] as well as developing mass spectrometry imaging technology using nanostructured surfaces.

[1][3][4][5][35][15][36][37][12] His initial efforts with Richard Lerner,[4] used liquid chromatography mass spectrometry to perform metabolomic experiments on the cerebral spinal fluid of sleep deprived animals.

This work is one of the earliest such experiments combining liquid chromatography mass spectrometry and metabolomics to identify active metabolites.

[4][1][3] Another notable activity metabolomics effort with Oscar Yanes (Spain) identified[5] neuroprotectin D1 as a metabolite that promotes stem cell differentiation.

[20] In 1999, the Siuzdak lab described the use of nanostructures to enhance desorption/ionization on porous silicon of small molecules (DIOS),[10] this is also known as the first surface-based example of surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS).

In 2020, the Siuzdak lab building off their work with Xavi Domingo[41] and METLIN,[12][39] developed Enhanced In-Source Fragmentation/Annotation (EISA)[27] to facilitate the fragmentation, identification, and quantification (via Q-MRM)[28][42] of molecules without the use of tandem mass spectrometry.