[1][2][3][4] Luis Córdoba Ronquillo was born in Quito and ordained a priest in the Order of Saint Augustine.

[2] On 20 April 1637, he was appointed during the papacy of Pope Urban VIII as Bishop of Santiago de Chile.

[2] On 11 December 1651, he was appointed during the papacy of Pope Innocent X as Bishop of Arequipa.

[1][2] On January 1659, he was appointed during the papacy of Pope Alexander VII as Archbishop of La Plata o Charcas and installed in 1660.

[1][2] He served as Archbishop of La Plata o Charcas until his death on 15 October 1665.