Gateway Regional Medical Center is an American hospital in Granite City, Illinois.

It contains 305 licensed beds, 100 of which are for treatment of acute mental illness in the behavioral health unit.

Peter Paul Kaenders, Pastor of St. Mark Catholic Church in Venice, Illinois,[5] who wanted to convert the hospital to serve the Catholic community of the region, which included a large German immigrant population.

Unsuccessful at first, Kaenders met Mother Aloysia Bansbach, the Provincial Superior of the Religious Sisters of the Congregation of Divine Providence—founded in Mainz, Germany—in the United States.

The Sisters of Divine Providence owned, operated and staffed the hospital until 2001, when it was sold and renamed Gateway Regional Medical Center.