[5][6][7] She did a lot of ramp shows and has done television commercials for many well known companies such as Sprite, Bru, Dabur, Pond's, Santoor, Colgate, Philips, Breeze, etc.

In October 2001, Pradhan rose to fame with tele-series Kutumb on Sony TV where she played the lead role of Gauri Agarwal Mittal.

Soon after in 2003, she did an episodic role as Shweta in Krishna Arjun on Star Plus, and she then appeared in another family drama named Naam Gum Jayegaa on Sony TV as the female lead Priyanka Singh.

After a string of cameos and a short series, Pradhan was approached in 2004 to play the lead as Nandini Thakkar in Kyunki Saas Bhi Kabhi Bahu Thi on Star Plus.

In the same year, she appeared in Isse Kehte Hai Golmaal Ghar that aired on Sahara One channel as the main lead opposite Manav Gohil.

Pradhan has also made special appearances in other Indian series like Rihaee and Jassi Jaissi Koi Nahin on Sony TV.

In 2009, Pradhan did a long cameo in Star Plus's afternoon long-running hit show Kumkum  – Ek Pyara Sa Bandhan as Aditi Kapoor along with her husband.

In 2014, after a long hiatus of five years, she made her comeback on television with Ekta Kapoor's show, Meri Aashiqui Tumse Hi (which aired on Colors TV) as Falguni Parekh.

[16] While playing the characters of star crossed lovers Karan and Nandini in another daily soap Kyunki Saas Bhi Kabhi Bahu Thi, they decided to get married.

[17] After two years of courtship, they got married as per Maharashtrian customs at a private ceremony in the Sun-n-Sand Hotel in Pune on 29 April 2004, with about 40–50 guests in attendance.