[2] Floyd, who had originally made a verbal commitment to attend the University of South Carolina, opted instead to play in major league baseball.

A highlight of his most impressive first season (2.77 ERA, .200 BAA) was pitching the first nine-inning no-hitter in BlueClaws history on July 24 against the Lexington Legends.

He was promoted to the Scranton/Wilkes-Barre Red Barons (AAA) in July and made five starts before having his contract purchased by Phillies as a September callup.

Floyd made his Major League debut September 3, 2004, against the division rival New York Mets and earned the win pitching seven strong innings allowing only one run on four hits, while striking out five.

[7] Floyd came to 2006 spring training with barely a consideration and pitched his way into the Phillies rotation as the #4 pitcher, pushing Ryan Franklin to the bullpen.

[15] He finished the regular season with a 17–8 record and a 3.84 ERA in 33 starts,[6] with his final win coming in a game which the White Sox beat the Detroit Tigers to force a one-game playoff with the Twins to determine the Central's winner.

[20] After an MRI revealed his elbow had a torn flexor muscle and UCL, Floyd underwent Tommy John surgery on May 7, 2013 and was shut down for the rest of the 2013 season.

[25] On December 16, 2014, Floyd signed a one-year, $4 million contract with the Cleveland Indians,[26] but was subsequently placed on the 60-day disabled list on April 5, 2015 after injuring his pitching elbow during spring training.

[29] Floyd entered spring training in competition for the fifth starter role with Aaron Sanchez, Drew Hutchison, and Jesse Chavez.

On January 5, 2017, Floyd signed a minor league contract with the Blue Jays which included an invitation to spring training.