[13] Early in her career, she insisted on being known by her full name to avoid confusion with another actress, Gayatri Jayaraman, who was also active in the period.

[16] The film enjoyed commercial success, with a critic from The Hindu stating "the new heroine's expertise in dance is particularly impressive".

In concern of her performance in the horror film Whistle (2003), a critic from The Hindu wrote "Gayathri Raghuram's face is and her expressions are just right but rotundity seems to come in the way of wholesome appeal".

[18] Likewise, a critic wrote "Gayathri, as the garrulous friend of the hero, begins well, and even when you think she might have a solid role to play, she turns out to be just another weighty heroine in tow", in regard of her appearance in the Arjun-starrer Parasuram (2003).

[13] Likewise, she made an extended guest appearance in director Bala's village drama Tharai Thappattai (2016), where she also featured in a karakattam-based song.

[22] She was evicted from the show o the 56th day, after having attracted widespread criticism for her behaviour inside the Bigg Boss House.

[26][27][28] In November 2015, Gayathri was appointed as Bharatiya Janata Party's secretary for arts in Tamil Nadu.

[30] Gayathri Raghuram was made as president of Arts and Culture Wing of Tamil Nadu BJP in July 2020.

[11] Gayathri has ever since started a campaign against Tamilisai and has gone on television and party members and said that the BJP will grow in Tamil Nadu if the leadership is changed.

[35] Gayatri Raghuram in November 2022, condemned the party's OBC state president Surya Siva for abusing and giving death threats to BJP's Minority Morcha leader Daisy Saran, and criticized the party's state president K. Annamalai for giving the post to Surya Siva.

[38] On 19 January 2024, She joined the All India Anna Dravida Munnetra Kazhagam in the presence of its general secretary Edappadi K.