The station will serve as the terminus of the Mersin to Gaziantep High Speed Rail Project being constructed by 2024.

[2]: 205  İstasyon Street was built as, and continues to be, a major axis in central Gaziantep, lined with trees and home to a number of important public buildings.

[2]: 199  Passengers heading to Gaziantep would disembark at Narlı and then travel the remaining distance by bus or private car, which would take about 5 hours.

[2]: 203  The main architect is apparently not known, but the initial contractor was Muammer Bozok and the work was later completed by the civil engineer Şahap Sicimoğlu.

[2]: 203–4  The station's official opening ceremony was held on 27 October 1953, and the prime minister Adnan Menderes was in attendance.

Gaziantep station's "assertive", monumental colonnaded façade belongs to the second national architectural movement, which was in vogue at the time of its construction.

[2]: 205  The train platforms are on the upper level, which is divided into two parts that are separated by the main entrance hall.