Fusion gene

[1] The identification of these fusion genes play a prominent role in being a diagnostic and prognostic marker.

In 1985 it was clearly established that the fusion gene on chromosome 22 produced an abnormal chimeric BCR::ABL1 protein with the capacity to induce chronic myeloid leukemia.

[12] Presence of certain chromosomal aberrations and their resulting fusion genes is commonly used within cancer diagnostics in order to set a precise diagnosis.

Chromosome banding analysis, fluorescence in situ hybridization (FISH), and reverse transcription polymerase chain reaction (RT-PCR) are common methods employed at diagnostic laboratories.

Recent developments such as high-throughput sequencing[13] and custom DNA microarrays bear promise of introduction of more efficient methods.

[15] The detecting methods to inventory gene fusion events on a large biological scale can provide insights about the multi modular architecture of proteins.

Biosynthesis of these purines occurs by similar, but not identical, pathways in different species of the three domains of life, the Archaea, Bacteria and Eukaryotes.

In recent years, next generation sequencing technology has already become available to screen known and novel gene fusion events on a genome wide scale.

Some researchers already developed a new tool called Transcriptome Viewer (TViewer) to directly visualize detected gene fusions on the transcript level.