[1][2][3][4] The firm has invested in 800+ businesses, including global companies such as Airbnb, Anduril Industries, Applied Intuition, Glean Technologies, Guild Education, HubSpot, Kayak, Datalogix, Datto, Livongo, Gusto, Zepto, Ramp, Deliveroo, Samsara, Stripe, Snap, Mistral, and Helsing.

[20] In March 2023, General Catalyst was a supporter of the Silicon Valley Bank (SVB), after U.S. regulators shut it down after a significant number of the bank's customers sought to withdraw funds after dropping stock prices.

[21][22] General Catalyst, which was a SVB customer,[23] organized a joint statement of support signed by more than 110 venture capital firms.

[24] In June 2024, General Catalyst acquired La Famiglia, a German venture capital firm, after which La Famiglia's founding partner Jeannette zu Fürstenberg became the managing director at General Catalyst, overseeing its European business.

[34][35] In October 2023, the company announced plans to acquire a health system and "then use it as a proving ground for technology that its portfolio companies sell, including generative artificial intelligence-powered solutions applied to health care problems.