She began her career playing leading roles in the Telemundo telenovelas Prisionera (2004), Dame Chocolate (2007) and Doña Bárbara (2008–2009).

[9] Upon returning to Miami, she continued private instruction and obtained a recurring role on the NBC daytime soap opera Days of Our Lives from November 2005 to January 2006.

[1] In addition to American television, Rodriguez landed Spanish-language roles and played dual leads as Rosita Amado and Violeta Hurtado in the primetime series Dame Chocolate, which aired on Telemundo.

[10] In 2012, Rodriguez had a substantial role as the love interest of Will Ferrell in the comedy film Casa de Mi Padre,[3] a spoof in the style of the Mexican soap operas of the 1970s.

[5] In February 2017, she appeared as the main female role in the music video for Romeo Santos's song Héroe Favorito.