The mission of the institute "is to understand biological processes which alter the genetic makeup of different organisms, as a basis for potential gene therapy and genome engineering techniques.
"[1] The institute specializes in applying computer tools to analysis of DNA and protein sequence information.
The majority of known superfamilies of DNA transposons were discovered or co-discovered at GIRI, including Helitron, Academ, Dada, Ginger, Kolobok, Novosib, Sola, Transib, Zator, PIF/Harbinger and Polinton/Maverick.
An ancient element from the Transib superfamily was identified as the evolutionary precursor of the Recombination activating gene.
GIRI has hosted three international conferences devoted to the genomic impact of eukaryotic transposable elements.