[1][2] It quickly became a destination site for convention planners representing business, civic, military, and professional associates across Pennsylvania.

[6][7] One of the grand opening ceremonies for the hotel included a formal presentation by a Pittsburgh chapter of The Gideons International, during the afternoon of June 21, 1922, at which time representatives of the organization presented a gift of Bibles to be placed in each hotel room.

[9] On September 30, 1922, Republican gubernatorial candidate Gifford Pinchot, delivered an address to the Women's Christian Temperance Union at its annual convention that was held at the Lycoming Hotel, which adhered strictly to the federal Prohibition laws that outlawed the sale of alcohol.

"[11] In 1975, hotelier Gus Genetti purchased the Lycoming Hotel, announcing that he planned to renovate the facility at an estimated cost of $250,000.

It is the second tallest building in Williamsport as the Trinity Episcopal Church stands 210 feet tall.