The main building (rue du Général Dufour 2) is the former École de Commerce (1901-1917), built by Grand-Théâtre architect Jacques-Élysée Goss.

It currently houses several concert halls, including a black box, a space dedicated to world music, a cinema and numerous classrooms.

The Salle de la Bourse (rue du Grütli 5) occupies the premises of the former Geneva Stock Exchange renovated by Goss (1915-1986), which have been transformed into an audition room and several lecture theatres.

The neighbouring buildings on rue Petitot 8-10 house, among other things, the Centre de musique électroacoustique and part of the Early Music department.

Built in the new Ecoparc district, the HEM Neuchâtel site occupies one of the two buildings of the Campus-Arc designed by Bauart and inaugurated on 15 and 16 May 2009.

A Cité de la Musique project at the Place des Nations in Geneva was launched in September 201315 with the support of a private foundation.

In autumn 2022, a new project was launched to create a building entirely dedicated to the HEM on the former premises of Radio-Télévision Suisse, which could house all the activities of the Geneva campus.