[citation needed] It is currently operated by Aeroporto di Genova S.P.A., which has recently upgraded the airport complex.

The airport is named after the notable Genoese navigator and explorer Christopher Columbus, who is recalled in the monument La Vela di Colombo.

[4][5] The airport was the manufacturing base for Piaggio Aerospace, an Italian aircraft design and production company.

[citation needed] In January 2022, Volotea announced to close their Genoa base after five years, leading to the cancellation of 14 routes.

[citation needed] The closest railway station to the airport is Genova Sestri Ponente-Aeroporto, served by Trenitalia regional trains to/from Piazza Principe/Brignole, Savona and Ventimiglia.