Genome Research is a peer-reviewed scientific journal published by Cold Spring Harbor Laboratory Press.

This scope includes genome structure and function, comparative genomics, molecular evolution, genome-scale quantitative and population genetics, proteomics, epigenomics, and systems biology.

New data in these areas are published as research papers, or methods and resource reports that provide novel information on technologies or tools that will be of interest to a broad readership.

The journal was established in 1991 as PCR Methods and Applications and obtained its current title in 1995.

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