After graduating from Andover College, he took a course in architecture at the newly founded MIT (known informally at the time as Boston Tech),[1] and then started in the office of his uncle, J.E.

[2] In New York, Fuller's design for a new club house for the Union League Club of New York, a Queen Anne mansion for the site at the corner of Fifth Avenue and 39th Street, won over eight other designs, including those submitted by noted architects Richard Morris Hunt and Charles McKim and William Rutherford Mead.

[3] Fuller moved to Chicago, the locus of much of the skyscraper construction in the United States at the time, where he formed a partnership with C. Everett Clark, another architect from Massachusetts, which lasted only two years.

[5] Very little is really known today of the properties of steel ... and though events point strongly to [it] becoming the metal of the future, there exists among many reasonable conservative men, a wide and well-grounded distrust of its use in the higher engineer or architectural structures, on account of its mysterious behavior, and frequent erratic and inexplicable failures.

[6]Fuller's firm built the Tacoma Building in Chicago designed by Holabird & Roche and completed in 1889, which was the first skyscraper with non load bearing curtain walls.

[8][9] The Fuller Company was also intensely involved in the building of the Chicago World's Fair of 1893, the Columbian Exposition, in which a temporary "White City on the Lake" was constructed under the supervision of Daniel Burnham.

[19] Black announced: The new company will undoubtedly enter foreign fields, with the view of introducing steel construction in cities like London, Paris and Berlin.

When the Fuller Company was implicated in the corruption of the building trades union leader, Samuel Parks, its stock fell.

[21] In 1920, together with Mitsubishi, he founded the George A.Fuller Company of The Orient Ltd. in Tokyo and built several private and government office buildings in the far east Asia.